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New study finds key diabetes gene

研究發現關鍵糖尿病基因

New study finds key diabetes gene

A single genetic change could predispose close to 40 percent of the population to type-2 diabetes, researchers said on Sunday.

週日,一項研究指出,一個單一基因的變體可能使百分之四十的人口易有罹患第二型糖尿病的傾向。

The gene, identified in a study of Iceland's comprehensive genetic records, is carried by 38 percent of the Northern European populations studied, and is also common among African-Americans, the researchers said.

此種基因被發現於冰島一項全面性的基因紀錄中,研究中顯示北歐有百分之三十八的人口帶有這種基因變體,並且也普遍存在於非洲裔美國人身上。

Writing in the journal Nature Genetics, Kari Stefansson of DeCode Genetics and colleagues said their finding could help in the development of an easy test for diabetes risk and might also lead to better drugs for the disease, which affects nearly 200 million people worldwide and 18 million people in the United States alone.

冰島「解碼基因」公司的凱利.史蒂芬森與同僚將此研究發表在「自然遺傳學」期刊上,他們表示該研究可能有助於發展出測試糖尿病風險的簡易方法以及更好的藥物。全球有近乎兩億的糖尿病患者,而美國就有一千八百萬人。

“If you have one copy of this variant, which 38 percent of people do, your risk of developing type-2 diabetes is increased by 40 percent,”Stefansson, who is chief executive officer of DeCode, said in a telephone interview.

「解碼基因」公司的執行長史蒂芬森於一電話專訪中表示:「假如你像那些百分之三十八的人口一樣擁有一基因變體,你罹患第二型糖尿病的風險就會增加百分之四十。」

“Seven percent have two copies and have a 140 percent increase in risk. If you remove this variant out of the population, you would remove basically 20 percent of the type-2 diabetes cases from our society.”

「百分之七的人有兩種基因變體,而他們罹患糖尿病風險提高百分之一百四十,如果你能把這種基因變體從人口中消除,基本上你就可以移除社會上百分之二十的第二型糖尿病病例。」

Type-2 diabetes was once known as adult-onset diabetes, and differs from type-1, or juvenile, diabetes. With an inability to use and produce insulin properly, sufferers end up with too much glucose in their blood and have high rates of heart disease, blindness, nerve damage and limb loss.

第二型糖尿病又為成人型糖尿病,與第一型(青少年型糖尿病)不同,患者無法適當分泌胰島素與發揮其功用,導致太多葡萄糖堆積在血液中,提高心臟疾病、眼瞎、神經傷害以及截肢的風險。

Type-2 diabetes is associated with obesity and a lack of exercise and is being found in children more commonly worldwide.

第二型糖尿病與肥胖以及缺乏運動有關,而且孩童患者在全球愈來愈普遍。

The variant his team found, called TCF7L2, is associated with a younger onset of the condition, and sufferers appear to be thinner than the average type-2 patient.

史蒂芬森的研究團隊發現,該變體稱為TCF7L2,與較年輕型有關,患者似乎比一般的第二型病患更瘦。

“This discovery sheds new light on the biological causes of the disease. Importantly, virtually all of this risk can be captured by looking at a single-letter change in DNA ?ideal for the development of a genetic test for assessing individual risk and developing more personalized and effective prevention strategies,” Stefansson said.

史蒂芬森表示:「這項發現闡明了疾病的生物學因素,最重要的是,實際上,這項疾病能夠透過DNA中單一字母的改變而獲知疾病風險,這對於評估個人疾病風險所發展的基因測試以及開發更多個人化且有效的疾病防治方法,是很理想的。」


Updated : 2021-06-18 11:06 GMT+08:00