TUSCALOOSA, Alabama (AP) -- Alabama's Derrick Henry ran for 210 yards and three touchdowns to lead the Crimson Tide to a 30-16 victory over Louisiana State on Saturday in a clash of two genuine contenders for the college football title.
Another two of the leading contenders, Texas Christian and Michigan State, had their credentials tarnished in losses at Oklahoma State and Nebraska respectively.
Top-ranked Ohio State improved to 9-0 this season with a victory over Minnesota.
Alabama physically dismantled the previously unbeaten LSU in the second half and smothered Tigers running back Leonard Fournette, who was limited to only 31 yards on 19 carries. His previous low this season was 154 yards.
Opposing tailback Henry had much more room and led the way with 38 punishing carries.
Oklahoma State quarterback Mason Rudolph threw for 352 yards and a career-high five touchdowns to lead the unbeaten Cowboys to a 49-29 win against Texas Christian.
James Washington caught five passes for 184 yards and three touchdowns for the Cowboys.
TCU's Trevone Boykin passed for 445 yards and ran for 73 yards and two touchdowns, but also threw a career-worst four interceptions.
Nebraska quarterback Tommy Armstrong drove the Cornhuskers offense 91 yards in 38 seconds and hit receiver Brandon Reilly with a 30-yard touchdown pass that survived a video review with 17 seconds left, giving the hosts a 39-38 win against Michigan State.
The last-gasp loss will likely ruin the Spartans' playoff hopes.
Armstrong rallied the Cornhuskers from 12 points down in the last 4 1/2 minutes. He scored on a short touchdown run with 1:47 left to make it 38-33.
Ohio State's Ezekiel Elliott ran 15 yards for a touchdown on the Buckeyes' only lengthy drive and the home team won 28-14 against Minnesota.
The Buckeyes struggled with Cardale Jones back at quarterback, but got a solid performance by their defense and just enough from everyone else to win their 22nd in a row.
Clemson wrapped up the Atlantic Coast Conference's Atlantic Division with a 23-13 win against Florida State.
Deshaun Watson threw a go-ahead touchdown pass to Deon Cain and Wayne Gallman came through with a game-sealing score.
Seminoles running back Dalvin Cook had only 37 yars rushing in the second half.
Notre Dame's DeShone Kizer threw five touchdown passes and ran for another score to lead the Fighting Irish to a 42-30 win against Pittsburgh and boost the team's College Football Playoff resume.
Kizer completed 19 of 26 passes for 262 yards with no turnovers in Notre Dame's fourth straight win. Will Fuller caught seven passes for 157 yards and three scores and Josh Adams ran for 147 yards and hauled in Kizer's final touchdown pass.
Stanford's Kevin Hogan threw two touchdown passes and had a scoring run as the Cardinal cruised past Colorado 42-10.
With his 32nd win, Hogan surpassed Andrew Luck for most wins by a Stanford quarterback.
Running back Christian McCaffrey had 220 all-purpose yards, and threw a 28-yard touchdown pass.
Iowa's LeShun Daniels Jr. ran for two scores and injured quarterback C.J. Beathard threw the clinching touchdown midway through the fourth quarter to help the Hawkeyes defeat Indiana 35-27.
The Hawkeyes improved to 9-0 to match the best start in team history.
AP college football website: www.collegefootball.ap.org