NEW YORK (AP) -- Michael Pineda struck out a career-high 16 batters in seven dominant innings as the New York Yankees downed the Baltimore Orioles 6-2.
Pineda (5-0) matched David Cone and David Wells for the second-most strikeouts in a game by a Yankees pitcher. Ron Guidry fanned 18 in 1978.
The 16 strikeouts were the most by the Orioles against one pitcher in a nine-inning game, according to STATS. Baltimore struck out against 18 times overall, a club record for a nine-inning game.
Bud Norris (1-4) took the loss. The Orioles dropped five of six during their week in New York against the Yankees and Mets.
ROYALS 2, TIGERS 1, 10 INNINGS
DETROIT (AP) -- Greg Holland worked out of a bases-loaded, nobody-out jam in the bottom of the 10th inning as Kansas City held on to beat Detroit 2-1 in a game that was delayed 103 minutes by rain.
Omar Infante's sacrifice fly in the top of the 10th put the Royals ahead, but Holland allowed a single and two walks to start the bottom half. Hernan Perez -- batting because Miguel Cabrera had been removed for a pinch-runner the previous inning -- bounced into a 5-2-3 double play, but another walk to Victor Martinez loaded the bases again.
Holland then struck out Yoenis Cespedes for his sixth save in six chances.
Jason Frasor (1-0) got the win, working out of a bases-loaded jam of his own in the ninth after the rain delay in the middle of the inning.
Angel Nesbitt (0-1) took the loss.
NATIONALS 5, BRAVES 4
WASHINGTON (AP) -- Streaking slugger Bryce Harper doubled, singled and drove in another run -- but didn't homer -- as Washington beat Atlanta 5-4 for a three-game sweep.
Harper had hit six home runs in his previous three games. He doubled home a run, giving him 13 RBIs in four games, and also scored once.
Wilson Ramos hit a tiebreaking double off Cody Martin (1-2) to cap a two-run rally in the eighth inning, sending the Nationals to their 10th win in 12 games. Ramos and Ryan Zimmerman each had a double, single and two RBIs.
Sammy Solis (1-0) pitched one inning for his first major league win and Drew Storen closed for his ninth save.
DODGERS 9, ROCKIES 5
DENVER (AP) -- After the snow was cleared from Coors Field, the Los Angeles Dodgers used Justin Turner's tiebreaking homer in the eighth inning to send the Colorado Rockies to their ninth straight loss, 9-5.
The series finale began on time after the first two games were affected by the wet weather that has socked Colorado for a week. The gametime temperature was 41 degrees and it dropped to 39 degrees in the ninth.
Turner's two-run homer highlighted a four-run burst in the eighth. Adrian Gonzalez hit two doubles and drove in four runs as the Dodgers beat Colorado for the eighth straight time dating to last season.
Dodgers ace Clayton Kershaw failed in his fourth bid for his 100th regular-season win. The reigning NL MVP and Cy Young Award winner gave up five runs on eight hits and four walks in 5 2-3 innings.
It was 5-all in the eighth when Turner connected off Scott Oberg (1-1) for his fifth homer.
Pedro Baez (1-0) pitched 1 1-3 innings for the win.
RED SOX 6, BLUE JAYS 3
TORONTO (AP) -- Mike Napoli hit a three-run homer and Pablo Sandoval added a two-run shot as Boston beat Toronto 6-3 to avoid a three-game sweep.
Clay Buchholz (2-4) allowed three runs in 6 1-3 innings for his first victory in six starts. The last-place Red Sox won for just the second time in nine games.
Carl Willis joined the Red Sox for his first game as their new pitching coach. He replaced Juan Nieves, who was fired Thursday.
Junichi Tazawa pitched 1 2-3 innings and Koji Uehara finished for his sixth save.
R.A. Dickey (1-4) lost for the third time in four starts.
BREWERS 3, CUBS 2, 11 INNINGS
MILWAUKEE (AP) -- Martin Maldonado singled over the Cubs' drawn-in outfield with one out in the 11th inning, lifting Milwaukee past Chicago.
After a 7-18 start, the Brewers went 4-3 in Craig Counsell's first week as manager since taking over for the fired Ron Roenicke.
Chicago went to a five-man infield and brought in their remaining two outfielders with the bases loaded. Maldonado, who homered earlier, hit a deep fly off Jason Motte (1-1).
Michael Blazek (3-0) pitched a perfect top of the 11th.
WHITE SOX 4, REDS 3
CHICAGO (AP) -- Gordon Beckham hit a game-winning single against Aroldis Chapman in the ninth as Chicago beat Cincinnati.
Chapman (1-1) got the first two outs of the inning, then gave up back-to-back singles to Avisal Garcia and Alexei Ramirez. They advanced to second and third on a wild pitch, then on a 2-2 pitch Beckham singled to center to end the game, breaking the tie.
It was Chapman's first earned run of the season in 12 2-3 innings.
White Sox closer David Robertson (3-0) couldn't hold a 3-1 lead in the ninth. He gave up back-to-back singles to start the inning to Devin Mesoraco and Bryan Pena. After a pass ball by Geovany Soto to advance the runners to second and third Zack Cozart doubled down the left-field line to tie the game.
MARINERS 4, ATHLETICS 3
SEATTLE (AP) -- Felix Hernandez became the fourth-youngest player to reach 2,000 career strikeouts while giving up two runs over seven innings to lead Seattle to a win against Oakland.
Hernandez, at 29 years, 32 days old, is behind only Bert Blyleven, Sam McDowell and Walter Johnson, who were all 28 when they reached 2,000 strikeouts.
The right-hander started Sunday's game against the Oakland Athletics with 1,995 strikeouts. In the fifth inning, Hernandez fell behind leadoff batter Sam Fuld 3-1 before striking him out looking at a fastball for No. 2,000.
Hernandez (6-0) added one more strikeout on his final batter, getting Eric Sogard swinging to end the seventh inning.
Marcus Semien hit two solo home runs off Hernandez for the first multi-homer game of his career.
Fernando Rodney pitched the ninth and earned his ninth save 10 chances.
Oakland starter Jesse Chavez (1-3) didn't give up a hit in the first three innings before running into trouble.
GIANTS 3, MARLINS 2
SAN FRANCISCO (AP) -- Matt Duffy singled in Gregor Blanco with two outs in the ninth inning to cap a two-run rally off closer Steve Cishek and lift San Francisco over Miami.
The Giants had been quiet offensively most of the game until breaking out against Cishek (1-2), who had not allowed an earned run in 13 previous appearances against the defending World Series champs.
Cishek struck out Justin Maxwell to open the ninth before getting into trouble. Andrew Susac singled and Blanco doubled. Joaquin Arias pinch-ran for Susac and stayed at third when pinch-hitter Buster Posey was intentionally walked to load the bases.
After pinch-hitter Angel Pagan struck out, Cishek walked Nori Aoki to force in the tying run. Duffy, hitless in his previous four at-bats, followed with the first game-ending hit of his career.
Santiago Casilla (4-0) retired two batters for the win, helping the Giants split the four-game series.
PIRATES 4, REDS 3
PITTSBURGH (AP) -- Jung Ho Kang went 2 for 4 with a home run and two RBIs and Pittsburgh beat St. Louis.
The Cardinals dropped two of three in Pittsburgh, their first series loss of the season.
With the game tied 3-3, Kang hit a go-ahead RBI single in the seventh inning.
Kang hit his second home run of the season in the first inning, a shot to left field off a 0-2 fastball left over the middle of the plate from St. Louis left-hander Tyler Lyons. Kang's home run gave Pittsburgh a 1-0 lead.
Jared Hughes (1-1) got the final out of the seventh for the victory.
Kang struck again for the Pirates in the seventh after pinch-hitter Steve Lombardozzi walked and advanced to second on a sac bunt. Kang singled to left off Mitch Harris to give Pittsburgh a 4-3 lead.
Harris (1-1) gave up a run on a hit and walked two in the seventh.
Mark Melancon earned his seventh save with a scoreless ninth.
METS 7, PHILLIES 4
PHILADELPHIA (AP) -- Bartolo Colon became the first pitcher in the majors with six wins, and Curtis Granderson hit a two-run homer to lead New York over Philadelphia.
Colon (6-1) won again despite giving up a homer to opposing pitcher Chad Billingsley (0-2). The right-hander, who turns 42 this month, allowed four runs with six strikeouts and no walks in six-plus innings.
Colon extended his streak without a walk to 40 1-3 innings, pulling closer to the franchise record of 47 set by Bret Saberhagen in 1994. The 2005 AL Cy Young Award winner has 40 strikeouts and one walk this season.
Daniel Murphy had three hits and pinch-hitter Johnny Monell delivered a two-run double for the Mets, who have won nine of 10 series against Philadelphia since 2012.
Jeurys Familia pitched a scoreless ninth for his NL-leading 13th save in as many opportunities.
INDIANS 8, TWINS 2
CLEVELAND (AP) -- Danny Salazar retired 21 straight batters after giving up a home run to start the game as Cleveland defeated Minnesota.
Salazar matched his career high with 11 strikeouts, including six in a row. He was removed after throwing 102 pitches in seven innings.
Brian Dozier's leadoff homer was the only hit Salazar (4-1) allowed. The right-hander struck out the side in the fifth and sixth.
Lonnie Chisenhall hit a three-run homer off Trevor May (2-3). Carlos Santana drove in three runs, Jason Kipnis had three hits and two RBIs, and David Murphy went 4 for 4 for the Indians.
Zach McAllister and Cody Allen finished the two-hitter. Cleveland pitchers combined for 16 strikeouts.
Minnesota had its four-game winning streak snapped and lost for the second time in 11 games.
RANGERS 2, RAYS 1
ST. PETERSBURG, Florida (AP) -- Adrian Beltre homered and drove in two runs, and Wandy Rodriguez gave Texas a record-setting pitching performance against Tampa Bay.
Beltre's tiebreaking single off Kevin Jepsen (0-2) came in the eighth inning following a couple of walks.
Keone Kela (3-1) got the win after Rodriguez established a franchise mark for consecutive batters retired.
The 36-year-old lefty set down the first 15 Rays before Tim Beckham led off the Tampa Bay sixth with a line-drive single. Following the 19 straight hitters Rodriguez retired in his previous start at Houston, he broke the team record of 31 in a row set by Ken Hill in 1996.
Rodriguez gave up two hits and struck out six in six innings. Neftali Feliz earned his fifth save.
ANGELS 3, ASTROS 1
ANAHEIM, California (AP) -- Garrett Richards took a no-hitter into the seventh inning as Los Angeles scored all its runs in the fifth en route to a victory that secured a four-game split with AL West-leading Houston.
Richards (3-1) walked his first batter of the day, then retired 15 in a row. The right-hander walked his first two in the seventh before striking out Colby Rasmus, but Jason Castro lined a clean single to left field to break up the no-hit bid.
Fernando Salas retired pinch-hitter Evan Gattis with the bases loaded to end the seventh. Huston Street got his 10th save in 12 attempts, following back-to-back blown saves Wednesday and Thursday.
Richards struck out 10 and walked four to win his third straight decision.
Scott Feldman (2-4) allowed three runs and six hits in seven innings.
DIAMONDBACKS 2, PADRES 1
PHOENIX (AP) -- Aaron Hill and A.J. Pollock homered to back five pitchers who carried Arizona to a tight victory over San Diego.
Daniel Hudson, making his first major league start since June 2012, was limited to 56 pitches in 3 1-3 scoreless innings. He's been used out of the bullpen since returning late last season from two Tommy John surgeries.
J.C. Ramirez (1-0), just called up from Triple-A, pitched out of two bases-loaded jams to earn his first career win. He allowed a run and four hits in 2 2-3 innings.
Oliver Perez, Evan Marshall and Addison Reed combined for three innings of scoreless relief. Reed earned his second save of the season.
Hill and Pollock homered off Andrew Cashner (1-6), who went seven innings.