WASHINGTON (AP) -- Drugmaker AbbVie is raising its full-year earnings guidance after reporting better-than-expected first quarter adjusted results on continued growth of its blockbuster anti-inflammatory drug Humira.
However, U.S. sales of the company's recently approved hepatitis C pill came in below expectations, underscoring concerns that the company is too reliant on Humira.
Sales of Humira, which is the world's top-selling prescription drug, increased 18 percent to $3.1 billlion. Humira is approved to treat more than a dozen conditions including rheumatoid arthritis, psoriasis and Crohn's Disease. But it will start losing patent protection next year and could eventually face competition from Amgen Inc., which is developing a biosimilar version of the drug.
That has focused attention on other AbbVie drugs with blockbuster potential, including Viekira Pak, a new hepatitis C medication approved in the U.S. in December. Company executives have predicted Viekira could reach annual sales of $3 billion by the end of 2015 with further growth in 2016 as the drug expands into new countries.
But U.S. sales of $138 million in the first quarter came in below expectations of $215 million, on average, according to a survey compiled by analyst Robyn Karnauskas of Deutsche Bank.
AbbVie's drug is competing against other hepatitis C drugs already established among physicians, namely Gilead Sciences' Sovaldi and Harvoni. All three treatments are considered major improvements from earlier drug options, but they have also faced criticism for their high costs. The list price for AbbVie's drug is $83,320, compared with a list price of $84,000 for Sovaldi and $94,000 for Harvoni.
The North Chicago-based company's quarterly results were weighed down by a $1.9 billion in one-time costs, including a breakup fee from its abandoned merger with Shire PLC. That left it with earnings of $1.02 billion, or 63 cents per share, for the first quarter.
Adjusted earnings were 94 cents per share on revenue of 5.04 billion, beating analyst estimates of 85 cents per share on revenue of $5.01 billion.
The company raised its full-year earnings to $4.10 to $4.30, from $4.05 to $4.25.
Shares of AbbVie Inc. fell $1.04, or 1.6 percent, to $63.49 in morning trading Thursday.
Following the break-up of its planned trans-Atlantic merger with Shire, AbbVie has pushed ahead with other efforts to diversify its offerings. Last month the company announced an agreement to buy fellow U.S. drugmaker Pharmacyclics for $21 billion to add another blockbuster product to its portfolio.
The deal will give AbbVie Imbruvica, a blood cancer treatment that Pharmacyclics makes and then markets with Johnson & Johnson's Janssen Biotech. AbbVie executives say their company could reap more than $7 billion in annual sales from Imbruvica in a few years.
Imbruvica is approved in more than 40 countries and treats three different types of blood cancers including chronic lymphocytic leukemia, which is the most common leukemia in adults.