MINNEAPOLIS (AP) -- The Kansas City Royals became the only unbeaten team in Major League Baseball as Danny Duffy pitched into the seventh inning and Kendrys Morales homered in a 12-3 romp over Minnesota, spoiling the Twins' home opener Monday.
The defending American League champions improved to 7-0. It's the second-best start in Kansas City's history, behind the 2003 club that won nine in a row to begin the season.
Detroit, which had been the only other undefeated team in MLB, lost 5-4 at Pittsburgh earlier in the day.
Duffy (1-0) went 6 1/3 innings, giving up three runs.
In other games, the Los Angeles Dodgers rallied for a 6-5 win over Seattle in 10 innings, Boston beat Washington 9-4 in their home opener, the New York Yankees beat Baltimore 6-5 for their first winning streak of the season, and Colorado spoiled San Francisco's World Series championship celebration with a 2-0 win.
Alex Guerrero hit a bases-loaded single with two outs in the bottom of the 10th inning, completing the Dodgers comeback from a four-run deficit for a victory over the Mariners.
Yasiel Puig homered and Howie Kendrick had a tying RBI single in the fifth for Los Angeles.
Nelson Cruz hit two of the Mariners' four home runs off Brandon McCarthy.
Mookie Betts hit a three-run homer, jumped to take away a home run from Bryce Harper and stole two bases on the same pitch to lead Boston to the win.
Rick Porcello (1-1) won his Fenway Park debut, allowing four hits in eight innings. The Red Sox rolled to an 8-0 lead after three innings against Jordan Zimmermann (1-1).
Stephen Drew delivered a pinch-hit grand slam in the seventh inning for the Yankees.
Down 4-2, the Yankees loaded the bases with two outs before Drew connected on a 3-1 pitch from Tommy Hunter (0-1). It was his second homer in two games and New York's first pinch-hit slam since Jorge Posada did it in 2001 against the Orioles.
Eddie Butler outpitched fellow rookie Chris Heston to lead Colorado to victory at the Giants' home opener.
Troy Tulowitzki hit an RBI single in the fourth inning against Heston. Butler (1-0) tossed 5 1-3 innings of five-hit ball, walking six.
San Francisco raised its third World Series winning flag in five years before the game.
In Pittsburgh, Gerrit Cole shut down baseball's top-hitting team, allowing one run in six-plus innings as Pittsburgh beat Detroit.
The Tigers were trying to match the 7-0 start set by the 1984 club that went on to win the World Series.
Cole (1-0) struck out eight and walked two while giving up three hits in the Pirates' home opener.
In Toronto, Jake Odorizzi pitched eight impressive innings and Tampa Bay scored on two bases-loaded walks by R.A. Dickey to beat the Blue Jays 2-1.
Odorizzi (2-0) allowed one run and two hits, improving to 2-0 with a 2.00 ERA in four career starts against the Blue Jays.
National League Rookie of the Year Jacob deGrom and the New York Mets won their home opener, shutting down Philadelphia 2-0. DeGrom (1-1) gave up seven hits in 6 1-3 innings.
Matt Garza overcame five walks to earn his first career win in St. Louis and Carlos Gomez had two hits and an RBI as Milwaukee beat the Cardinals 5-4.
Elsewhere, Oakland beat Houston 8-1, the Los Angeles Angels defeated Texas 6-3, the Chicago Cubs edged Cincinnati 7-6 in 10 innings, Atlanta outlasted Miami 3-2, and Arizona defeated San Diego 8-4.