Three South African teams, led by the conference-leading Stormers, provide the fly-in opposition for New Zealand and Australian sides as Super Rugby reaches the one-third point of its season this weekend.
The Stormers, who lead the South Africa conference by a point over the Sharks, play the Highlanders at Dunedin, New Zealand on Saturday just after the Cheetahs, based in Bloemfontein, take on the Chiefs at Hamilton.
On Friday, the league-leading Hurricanes host the Melbourne Rebels a few hours before the Queensland Reds host the Johannesburg-based Lions in Brisbane.
Rebels captain Scott Higginbotham is expected to play his 100th Super match in the match at Wellington. Chiefs captain Liam Messam has been cleared to play against the Cheetahs despite being cited for a dangerous tackle in a match last weekend.